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Clicks: 70 2019 Photocatalytic health indications of biomass for hydrogen production over ZnS nanoparticles modified carbon nitride nanosheets. Javascript is currently disabled in your browser. The above percentage of manuscripts have been rejected in the last 12 months. In this study, we used A6K, a self-assembling surfactant-like peptide, as a carrier to encapsulate and deliver hydrophobic pyrene.

Methods: Pyrene was mixed with A6K by magnetic stirring to form a suspension. Confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, atomic force microscopy, fluorescence, and cell uptake measurements were carried out to study the features and stability of the nanostructures, the state and content of pyrene, as well bayer falcon the pyrene release profile.

Results: The suspension formed contained pyrene monomers trapped in the hydrophobic cores of the micellar nanofibers formed by A6K, as well as nanosized pyrene crystals wrapped up and stabilized by the nanofibers.

The two different encapsulation methods greatly increased the concentration of pyrene in the suspension, and formation of pyrene crystals wrapped up by A6K nanofibers might be the major contributor to this effect. Furthermore, the suspension system could readily release and transfer pyrene into living cells. Conclusion: A6K could be further exploited as a promising delivery system for hydrophobic drugs.

Keywords: pyrene, self-assembling peptide, micelles, nanofibers, drug deliveryIn the list of popular pharmaceutical chemicals, there are many important hydrophobic drugs, such as doxorubicin and paclitaxel for cancer chemotherapy and propofol for general anesthesia. Although basically effective, these drugs have poor solubility in aqueous solution, which has always been a drawback limiting the development of more available and effective formulations.

For this reason, much research has been conducted to increase the solubility and thus the bioavailability of Increlex (Mecasermin [rDNA origin] Injection)- FDA hydrophobic drugs. Surfactant-like peptide is a type of self-assembling peptide designed by mimicking the structure of traditional surfactant.

When first introduced about 10 years ago, A6K and other surfactant-like peptides were observed to form bilayered Increlex (Mecasermin [rDNA origin] Injection)- FDA and nanotubes, which were Increlex (Mecasermin [rDNA origin] Injection)- FDA to be potential carriers for biological molecules.

Recently, our group found that, when directly dissolved in pure water, A6K could form micellar nanofibers with a hydrophobic core and a very high aspect ratio,37 indicating that it should be investigated as a possible delivery system for hydrophobic drugs. Pyrene is a well-studied molecule with strong hydrophobicity and characterized fluorescence, making it a perfect model molecule for the investigation of delivery systems for hydrophobic drugs. The nanostructures of pyrene-A6K complex were studied, and then the content and fluorescence properties of encapsulated Increlex (Mecasermin [rDNA origin] Injection)- FDA were analyzed.

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